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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. As to TPGS based formulations, the limitations to realize the precise stimuli-responsive property and deep penetration of nanoformulations in tumor microenvironment still remain as obstacles for the widespread application of these nanomedicines. The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins. Further evaluation on in vivo pharmacokinetics and tumor growth inhibition also evidenced the great potential of this redox-responsive polymer for cancer treatment. TPGS can significantly increase the intracellular accumulation of Rh in drug-resistant tumor cells compared with free Rh, which was evidenced from the flow cytometry and confocal microscope analysis [ 32 ]. Suksiriworapong et al. Internal duplication and homology with bacterial transport proteins in the mdr1 P-glycoprotein gene from multidrug-resistant human cells.

Mol Med Rep. It can be also used as a targeting peptide to decorate on the surface of nanoparticles as overexpressed NRP-1 on tumor and angiogenesis cells. The schematic presentation of ROS-triggered and regenerating antitumor nanosystem. Free Radic Biol Med. Enhanced oral bioavailability of ursolic acid nanoparticles via antisolvent precipitation with TPGS as a stabilizer. Oral Maxillofac. Nat Rev Cancer.