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Pluripotent adult stem cells are rare and generally small in number, but they can be found in umbilical cord blood and other tissues. It is unclear why several months are necessary before MAPC colonies start to grow in bone marrow cultures and it has been suggested that the cells may represent a tissue culture specific cell with no in vivo counterpart. The formation of embryoid bodies in vitro by homogeneous embryonal carcinoma cell cultures derived from isolated single cells. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. In the mids, developmental biologists discovered that teratocarcinomas could be induced in mice by transferring embryos to extra-uterine sites and that they contained undifferentiated stem cells. Furthermore, cells from a clonal stem cell line WB-F , derived from an adult rat liver, were injected into the left ventricle of mice.

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